Denamarin for Medium Dogs Tablet 225 mg, Pack of 30 Tablets

Product Information

Denamarin for dogs and cats is a patented nutritional supplement for veterinary use in dogs and cats. Denamarin combines a pure and stabilized S-Adenosylmethionine with Silybin to provide a multi-faceted approach to liver support. How should Denamarin Tablets be given? Denamarin is available as enteric-coated tablets for dogs and cats and in tasty chewable tablets for dogs. Advanced technology in the exclusive NMXSS75 ® S-Adenosylmethionine found in the chewable formulation provides stability, eliminating the need for enteric coating or foil-on-foil blistering. The chewable tablets Dexamethasone can be administered in various forms including oral tablets, injectable solutions, and topical treatments. The mode of administration will depend on the condition being treated and your dog’s overall health. 10. Are there any natural alternatives to dexamethasone for managing inflammation in dogs?

Signs of overdose may include excessive thirst, increased urination, extreme hunger, and potential behavioral changes. In severe cases, it can lead to more serious symptoms. If you suspect an overdose, seek veterinary attention immediately. 12. Can dexamethasone be used in pregnant or nursing dogs? Plasma levels in dogs after oral administration of silymarin versus SPC (silybin-phosphatidylcholine complex). Each was given at the same amount based on silybin content (178mg). 13 Safety Denamarin combines a pure S-Adenosylmethionine (SAMe) with silybin to provide a one-two punch to keep your pets liver healthy. Silybin supports the flow of bile through the liver which helps with the digestion and absorption of nutrients from your pet's diet. Silybin also helps to regenerate liver cells and may enhance levels of glutathione, an antioxidant that helps to protect cells from toxins such as free radicals. Brand Name:There are no known drug interactions or contraindications to the use of silybin/silymarin in animals. 33,34 While mild side effects, such as gastrointestinal upset, itching and headache, have been rarely reported in primates, 33,35,36 no side effects have been noted in dogs or cats. 13,16,33,34,37,38 The specific silybin-phosphatidylcholine complex in Denamarin has been evaluated in both acute and chronic use safety studies: an acute toxicity study in dogs using levels greater than 80x the amount in Denamarin revealed no adverse physiologic effects, 38 and a chronic toxicity study in monkeys who received greater than 80x the amount in Denamarin for 26 weeks showed no compound-related adverse effects. 35 Administration As A Nutritional Supplement While natural supplements like fish oil, turmeric, and certain herbs are known for their anti-inflammatory properties, they are generally not as potent as dexamethasone. They may be used in mild cases or as adjunct therapy, but it’s important to consult with your vet before starting any natural supplements. 11. What are the signs of an overdose of dexamethasone in dogs? Denamarin can be used in conjunction with Marin ® to provide additional silybin levels and the benefits of vitamin E and zinc supplementation. If Marin is used in conjunction with Denamarin, the two products should be administered 12 hours apart for best response. Storage

Silybin is an antioxidant that helps to protect against harmful free radicals, further supporting your pet’s liver function. It also supports the flow of bile through the liver, helping your pet digest and absorb food effectively. As well as helping the liver to effectively perform it also helps with liver repair and increases levels of glutathione. nutramax LABORATORIES, VETERINARY SCIENCES, INC., 1550 Yorkton Ct, Unit 13, Burlington, ON L7P 5B7 Canada There are no known drug interactions or contraindications to the use of silybin/silymarin in animals. 33,34 While mild side effects, such as gastrointestinal upset, itching and headache, have been rarely reported in primates, 33,35,36 no side effects have been noted in dogs or cats. 13,16,33,34,37,38 The specific silybin-phosphatidylcholine complex in Denamarin has been evaluated in both acute and chronic use safety studies: an acute toxicity study in dogs using levels greater than 80x the amount in Denamarin revealed no adverse physiologic effects, 38 and a chronic toxicity study in monkeys who received greater than 80x the amount in Denamarin for 26 weeks showed no compound-related adverse effects. 35 Administration As A Liver Health Supplement Important: The exact dosage and duration of treatment should be determined by a vet. Potential Side Effects Dexamethasone, like other corticosteroids, can suppress the immune system, particularly at higher doses or with prolonged use. This suppression might make a dog more susceptible to infections. It’s crucial to keep a close eye on any signs of infection and maintain good health practices. 16. Is it safe to abruptly stop dexamethasone treatment in dogs?The number of tablets administered may be gradually reduced or increased at any time at your veterinarian’s recommendation.

Silybin/silymarin has many different mechanisms of action. Studies have shown that it protects against oxidative stress in multiple cell types and species. 20-23 A study in cats showed that it increased intracellular glutathione levels in neutrophils and increased phagocytic function. 21 Other research has shown that it promotes hepatocyte protein synthesis, 24 a mechanism for liver cell regeneration; inhibits IL-1β-induced production of several mediators (PGE 2, IL-8, and MCP-1) and translocation of NF-KB (nuclear factor-kappaB), a key signaling agent; 25 inhibits leukotriene production, 26,27 which can be beneficial as production of leukotrienes is a component of the inflammatory response; stimulates biliary flow and production of hepatoprotective bile salts (e.g., beta-muricholate and ursodeoxycholate); 28 and increases levels of glutathione. 29 The number of tablets administered may gradually be reduced, or increased, at any time at the recommendation of your veterinary surgeon.For cats and small dogs up to 12 pounds give 1 tablet of the small size. For medium dogs 13 to 34 pounds give 1 tablet of the medium size. For large dogs 35 to 65 pounds give 1 tablet of the large size. For large dogs 66 to 120 pounds give 2 tablets of the large size, and for large dogs over 120 pounds give 3 tablets of the large size. The tablets should be given on an empty stomach at least one hour before a meal for optimal absorption, typically one hour before feeding in the morning. For owners who find it difficult to administer tablet(s) to their pets, Denamarin may be disguised in a small bite of food. The number of tablets administered may be gradually reduced, or increased, at any time at the recommendation of your veterinarian. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled. Denamarin Chewable Tablets is a non-prescription (OTC) product available in bottles of 30 liver flavored chewable tablets for dogs of all sizes. High-Quality Ingredients: The Silybin found in Denamarin has shown better absorption by dogs and cats than the standardized milk thistle extract found in many other products It is also worth bearing in mind that Denamarin is often used alongside other drugs and treatments, you may not be able to rely solely on this nutritional supplement. Always follow your vet’s advice regarding treatment for your pet as some liver conditions may also need prescription medications such as antibiotics. For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. For those owners who have difficulty administering tablets to their pets, Denamarin tablet(s) may be disguised in a small bite of food. Studies have shown that, in many cases, tablets or capsules given as a “dry swallow” do not pass into the stomach in cats but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach. 39,40 Denamarin for Cats and Small Dogs tablets are ideal for cats because of their small size. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening.

Termination Notice. Walmart Inc. (“Walmart”) and Agropec Trading, LLC d/b/a Allivet ("Allivet") have terminated their agreement whereby Allivet Pet Pharmacy provided your pet pharmacy services. WalmartPetRx.com will continue to be operated by Allivet Pet Pharmacy solely in accordance with the dates below. Support Your Dog and Cat's Liver Health: The liver is one of the most vital organs in your pet and is responsible for removing toxins, storing energy, aiding digestion, and supporting the immune system Liver Support for Dogs: Denamarin is the #1 veterinarian recommended liver support supplement for dogs. This supplement contains s-adenosylmethionine (SAMe) to help increase levels of the antioxidant glutathione - one of the liver's main detoxifying agents You should always speak to your vet for advice on supplements before giving your pet anything new. There may be other treatment options that need to be explored alongside nutritional products.Denamarin ® Advanced tablets should be given on an empty stomach, at least one hour before a meal for optimal absorption. For cats, it is suggested that tablets should be followed immediately with a small amount of water to make sure the tablet passes all the way into the stomach. If pilling the dog or cat is not possible, the tablet may be administered with a small amount of food.